<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
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      <dc:title>A systematic review of the effects of increasing arachidonic acid intake on PUFA status, metabolism and health-related outcomes in humans</dc:title>
      <dc:creator>Calder, Philip C.</dc:creator>
      <dc:creator>Campoy Folgoso, Cristina</dc:creator>
      <dc:subject>Arachidonic acid</dc:subject>
      <dc:subject>n-6 Fatty acids</dc:subject>
      <dc:subject>Fatty acids</dc:subject>
      <dc:subject>Human health</dc:subject>
      <dc:subject>Inflammation</dc:subject>
      <dc:description>We conducted a systematic review of randomised controlled trials (RCT) of increased intake of arachidonic acid (ARA) on fatty acid status and&#xd;
health outcomes in humans. We identified twenty-two articles from fourteen RCT. Most studies were conducted in adults. These used between&#xd;
80 and 2000 mg ARA per d and were of 1–12 weeks duration. Supplementation with ARA doses as low as 80 mg/d increased the content of&#xd;
ARA in different blood fractions. Overall there seem to be few marked benefits for adults of increasing ARA intake from the typical usual intake of&#xd;
100–200 mg/d to as much as 1000 mg/d; the few studies using higher doses (1500 or 2000 mg/d) also report little benefit. However, there may be&#xd;
an impact of ARA on cognitive and muscle function which could be particularly relevant in the ageing population. The studies reviewed here&#xd;
suggest no adverse effects in adults of increased ARA intake up to at least 1000–1500 mg/d on blood lipids, platelet aggregation and blood&#xd;
clotting, immune function, inflammation or urinary excretion of ARA metabolites. However, in many areas there are insufficient studies to make&#xd;
firm conclusions, and higher intakes of ARA are deserving of further study. Based on the RCT reviewed, there are not enough data to make any&#xd;
recommendations for specific health effects of ARA intake.</dc:description>
      <dc:date>2020-03-10T11:54:14Z</dc:date>
      <dc:date>2020-03-10T11:54:14Z</dc:date>
      <dc:date>2019-05-27</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Calder, P. C., Campoy, C., Eilander, A., Fleith, M., Forsyth, S., Larsson, P. O., ... &amp; Mensink, R. P. (2019). A systematic review of the effects of increasing arachidonic acid intake on PUFA status, metabolism and health-related outcomes in humans. British Journal of Nutrition, 121(11), 1201-1214.</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/60184</dc:identifier>
      <dc:identifier>10.1017/S0007114519000692</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>Cambridge University Press</dc:publisher>
   </ow:Publication>
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