<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/60147">
      <dc:title>ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents</dc:title>
      <dc:creator>Barja Fernández, Silvia</dc:creator>
      <dc:creator>Aguilera García, Concepción María</dc:creator>
      <dc:subject>ANGPTL-4</dc:subject>
      <dc:subject>BMI loss</dc:subject>
      <dc:subject>Childhood</dc:subject>
      <dc:subject>Lipid profile</dc:subject>
      <dc:subject>Obesity</dc:subject>
      <dc:description>Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy&#xd;
homeostasis. However, its function in children with obesity remains unknown. We investigated&#xd;
plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different&#xd;
lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two&#xd;
different cohorts. In the first cohort (n = 150, age 3–17 years), which included children with normal&#xd;
weight or obesity, we performed a cross-sectional study. In the second cohort, which included only&#xd;
children with obesity (n = 20, age 5–18 years) followed up for two years after an intervention for&#xd;
weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after&#xd;
BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with&#xd;
obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with&#xd;
BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index&#xd;
(HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change&#xd;
in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant&#xd;
association of ANGPTL-4 with pediatric obesity and plasma lipid profile.</dc:description>
      <dc:date>2020-03-09T12:56:56Z</dc:date>
      <dc:date>2020-03-09T12:56:56Z</dc:date>
      <dc:date>2019-06-14</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Barja-Fernández, S., Folgueira, C., Castelao, C., Pena-León, V., González-Saenz, P., Vázquez-Cobela, R., ... &amp; Moreno, L. A. (2019). ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents. Nutrients, 11(6), 1340.</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/60147</dc:identifier>
      <dc:identifier>10.3390/nu11061340</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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