Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study Riquelme Gallego, Blanca Inactive time Light physical activity Moderate-to-vigorous physical activity Time in bed Cardiometabolic risk Isotemporal substitution This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Inactive time was associated with indicators of obesity and the metabolic syndrome. Reallocating 30min per day of inactive time to 30 min per day of time in bed was associated with lower BMI, waist circumference and glycated hemoglobin (HbA1c) (all p-values < 0.05). Reallocating 30 min per day of inactive time with 30 min per day of LPA or MVPA was associated with lower BMI, waist circumference, total fat, visceral adipose tissue, HbA1c, glucose, triglycerides, and higher body muscle mass and HDL cholesterol (all p-values < 0.05). Inactive time was associated with a poor cardio-metabolic profile. Isotemporal substitution of inactive time with MVPA and LPA or time in bed could have beneficial impact on cardio-metabolic health. 2020-03-03T12:05:43Z 2020-03-03T12:05:43Z 2019 info:eu-repo/semantics/article Galmes-Panades, A. M., Varela-Mato, V., Konieczna, J., Wärnberg, J., Martínez-González, M. Á., Salas-Salvadó, J., ... & Martínez, J. A. (2019). Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study. International Journal of Behavioral Nutrition and Physical Activity, 16(1), 1-12. http://hdl.handle.net/10481/59961 10.1186/s12966-019-0892-4 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Springer Nature