Alkylphenolic compounds and risk of breast and prostate cancer in the MCCSpain study Jiménez Moleón, José Juan Alkylphenols Alkylphenolic compounds Job-exposure matrix Breast cancer Prostate cancer Occupational exposure Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. We carried out a population-based case–control study including 1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to alkylphenolic compounds was estimated using a recently developed job-exposure matrix, which considered different scenarios of exposure and different subtypes of alkylphenolic compounds. Results: History of occupational exposure to alkylphenolic compounds was modestly associated with breast cancer (OR=1.23; 95% CI=1.01–1.48). Within the different scenarios, the occupational use of domestic tensioactives was positively associated with breast cancer (OR=1.28; 95% CI=1.02–1.60), while occupational exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol ethoxylates was positively associated with breast cancer (OR=1.21; 95% CI=1.00–1.47), while exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic, hair and personal hygiene products. Our findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings warrant further corroboration in other studies. 2020-02-14T10:14:52Z 2020-02-14T10:14:52Z 2019 journal article Peremiquel-Trillas, P., Benavente, Y., Martín-Bustamante, M., Casabonne, D., Pérez-Gómez, B., Gómez-Acebo, I., ... & Mengual, L. (2019). Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study. Environment international, 122, 389-399. http://hdl.handle.net/10481/59670 10.1016/j.envint.2018.12.007 eng http://creativecommons.org/licenses/by/3.0/es/ open access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Atribución 3.0 España Elsevier BV