Evaluation of metabolic changes in liver and serum of streptozotocininduced diabetic rats after Mango diet supplementation Fernández Ochoa, Álvaro Cázares Camacho, Rosario Borras Linares, María Isabel Domínguez Ávila, J. Abraham Segura Carretero, Antonio González Aguilar, Gustavo Adolfo 'Ataulfo’ mango Mangifera indica L Diabetes mellitus Metabolomics Mass spectrometry Mango consumption has shown bioactive properties against several diseases like diabetes, therefore, we evaluated how a mango-supplemented diet affects metabolic pathways in diabetic rats. Serum and liver samples were collected from 26 rats divided into 3 groups (healthy, untreated diabetic and mango-treated diabetic) after dietary intervention and analysed using an LC-MS untargeted metabolomic strategy. Twenty-six and 29 metabolites in serum and liver were potentially annotated, showing significant differences among groups. Several affected pathways were due to the disease state [fatty acids (i.e. palmitoleic, linolenic, stearidonic, eicosapentaenoic, docosahexaenoic acids and others), bile acids (i.e. glycocholic acid) and amino acids (i.e. leucine, isoleucine and valine)], and others due to mango supplementation (increased hepatic bioaccumulation of euxanthone, a mangiferin metabolite, and increased glutathione concentration). These results suggest that a mango-supplemented diet exerted a significant antioxidant effect in the liver of diabetic rats, likely due to its phenolic compounds, like mangiferin and its metabolites. 2020-02-11T12:43:31Z 2020-02-11T12:43:31Z 2020 info:eu-repo/semantics/article Fernández-Ochoa, Á., Cázares-Camacho, R., Borrás-Linares, I., Domínguez-Avila, J. A., Segura-Carretero, A., & González-Aguilar, G. A. (2020). Evaluation of metabolic changes in liver and serum of streptozotocin-induced diabetic rats after Mango diet supplementation. Journal of Functional Foods, 64, 103695. http://hdl.handle.net/10481/59579 10.1016/j.jff.2019.103695 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España Elsevier BV