Evaluation of metabolic changes in liver and serum of streptozotocininduced diabetic rats after Mango diet supplementation Fernández Ochoa, Álvaro Cázares Camacho, Rosario Borrás-Linares, Isabel Domínguez Ávila, J. Abraham Segura Carretero, Antonio González Aguilar, Gustavo Adolfo 'Ataulfo’ mango Mangifera indica L Diabetes mellitus Metabolomics Mass spectrometry Mango consumption has shown bioactive properties against several diseases like diabetes, therefore, we evaluated how a mango-supplemented diet affects metabolic pathways in diabetic rats. Serum and liver samples were collected from 26 rats divided into 3 groups (healthy, untreated diabetic and mango-treated diabetic) after dietary intervention and analysed using an LC-MS untargeted metabolomic strategy. Twenty-six and 29 metabolites in serum and liver were potentially annotated, showing significant differences among groups. Several affected pathways were due to the disease state [fatty acids (i.e. palmitoleic, linolenic, stearidonic, eicosapentaenoic, docosahexaenoic acids and others), bile acids (i.e. glycocholic acid) and amino acids (i.e. leucine, isoleucine and valine)], and others due to mango supplementation (increased hepatic bioaccumulation of euxanthone, a mangiferin metabolite, and increased glutathione concentration). These results suggest that a mango-supplemented diet exerted a significant antioxidant effect in the liver of diabetic rats, likely due to its phenolic compounds, like mangiferin and its metabolites. 2020-02-11T12:43:31Z 2020-02-11T12:43:31Z 2020 info:eu-repo/semantics/article Fernández-Ochoa, Á., Cázares-Camacho, R., Borrás-Linares, I., Domínguez-Avila, J. A., Segura-Carretero, A., & González-Aguilar, G. A. (2020). Evaluation of metabolic changes in liver and serum of streptozotocin-induced diabetic rats after Mango diet supplementation. Journal of Functional Foods, 64, 103695. http://hdl.handle.net/10481/59579 10.1016/j.jff.2019.103695 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España Elsevier BV