<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/59414">
      <dc:title>Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study</dc:title>
      <dc:creator>Gutiérrez González, Enrique</dc:creator>
      <dc:creator>Salcedo Bellido, Inmaculada</dc:creator>
      <dc:subject>Dietary zinc</dc:subject>
      <dc:subject>Prostate cancer</dc:subject>
      <dc:subject>Diet</dc:subject>
      <dc:subject>Genetic susceptibility</dc:subject>
      <dc:description>Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic&#xd;
cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies&#xd;
is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study,&#xd;
considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incident&#xd;
cases and 1228 population-based controls were included for this study. Dietary zinc was assessed&#xd;
using a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotide&#xd;
polymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increased&#xd;
risk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidence&#xd;
interval (CI):1.00–1.95). This association was mainly observed in low grade PC (Gleason = 6 RRR&#xd;
tertile 3vs1: 1.76; 95% CI:1.18–2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95%&#xd;
CI:1.00–1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89–2.53). In conclusion,&#xd;
a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men with&#xd;
higher genetic susceptibility might also have a higher risk of PC associated with this nutrient intake.</dc:description>
      <dc:date>2020-02-04T11:53:54Z</dc:date>
      <dc:date>2020-02-04T11:53:54Z</dc:date>
      <dc:date>2018-12-20</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Gutiérrez-González, E., Castelló, A., Fernández-Navarro, P., Castaño-Vinyals, G., Llorca, J., Salas-Trejo, D., ... &amp; Gracia-Lavedan, E. (2019). Dietary zinc and risk of prostate cancer in Spain: MCC-Spain study. Nutrients, 11(1), 18.</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/59414</dc:identifier>
      <dc:identifier>10.3390/nu11010018</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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