Exercise Training as a Treatment for Cardiometabolic Risk in Sedentary Adults: Are Physical Activity Guidelines the Best Way to Improve Cardiometabolic Health? The FIT-AGEING Randomized Controlled Trial Amaro Gahete, Francisco José De la O Puerta, Alejandro Jurado Fasoli, Lucas Martínez Téllez, Borja Manuel Ruiz Ruiz, Jonatan Castillo, Manuel J. Concurrent training Cholesterol Insulin resistance Insulin sensitivity Whole-body electromyostimulation Triglycerides This 12-week randomized controlled trial investigates the effects of different training modalities on cardiometabolic risk in sedentary, middle-aged adults, and examines whether alterations in cardiometabolic risk are associated with changes in those health-related variables that are modifiable by exercise training. The study subjects were 71 middle-aged adults (~54 years old; ~50% women) who were randomly assigned to one of the following treatment groups: (1) no exercise (control group), (2) concurrent training based on international physical activity recommendations (PAR group), (3) high intensity interval training (HIIT) group, or (4) HIIT plus whole-body electromyostimulation (HIIT+EMS group). A cardiometabolic risk score was calculated based on the International Diabetes Federation’s clinical criteria. A significant reduction in cardiometabolic risk was observed for all exercise training groups compared to the control group (all p < 0.05), which persisted after adjusting potential confounders (all p < 0.05). However, the HIIT+EMS group experienced the most significant reduction (p < 0.001). A significant inverse relationship was detected between the change in lean mass and the change in cardiometabolic risk (p = 0.045). A 12-week exercise training programs-especially the HIIT+EMS program-significantly reduced cardiometabolic risk in sedentary, middle-aged adults independent of sex, age, and cardiorespiratory fitness. 2020-01-31T09:18:58Z 2020-01-31T09:18:58Z 2019-12-01 journal article Amaro-Gahete, F. J., De-la-O, A., Jurado-Fasoli, L., Martinez-Tellez, B., R Ruiz, J., & Castillo, M. J. (2019). Exercise Training as a Treatment for Cardiometabolic Risk in Sedentary Adults: Are Physical Activity Guidelines the Best Way to Improve Cardiometabolic Health? The FIT-AGEING Randomized Controlled Trial. Journal of Clinical Medicine, 8(12), 2097. http://hdl.handle.net/10481/59320 10.3390/jcm8122097 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI