Montmorillonite-norfloxacin nanocomposite intended for healing of infected wounds García Villén, Fátima Aguzzi, Carola Cerezo González, María Pilar Viseras Iborra, César Antonio Montmorillonite Norfloxacin Nanocomposite Solid state characterization Wound healing The aim of this study was the design of a clay mineral-drug nanocomposite based on montmorillonite and norfloxacin (NF, antimicrobial drug) as a powder for cutaneous application, to enhance wound healing in infected skin lesions. The clay drug adsorption isotherm demonstrates that the mechanism of NF intercalation into montmorillonite galleries is the adsorption as one single process, due to the charge–charge interaction between protonated NF and negatively charged montmorillonite edges in the interlayer space. Nanocomposite is biocompatible and it is characterized by antimicrobial activity greater than the free drug: this is due to its nanostructure and controlled drug release properties. Considering the results obtained, NF–montmorillonite nanocomposite seems a promising tool to treat infected skin lesions or skin wounds prone to infection, as chronic ulcers (diabetic foot, venous leg ulcers) and burns. 2020-01-30T11:49:42Z 2020-01-30T11:49:42Z 2019 info:eu-repo/semantics/article García-Villén, F., Faccendini, A., Aguzzi, C., Cerezo, P., Bonferoni, M. C., Rossi, S., ... & Viseras, C. (2019). Montmorillonite-norfloxacin nanocomposite intended for healing of infected wounds. International journal of nanomedicine, 14, 5051. http://hdl.handle.net/10481/59284 eng http://creativecommons.org/licenses/by-nc/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial 3.0 España Dove Medical Press