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      <dc:title>liqDB: a small-RNAseq knowledge discovery database for liquid biopsy studies</dc:title>
      <dc:creator>Aparicio Puerta, Ernesto</dc:creator>
      <dc:creator>Jáspez, David</dc:creator>
      <dc:creator>Lebrón Aguilar, Ricardo</dc:creator>
      <dc:creator>Koppers-Lalic, Danijela</dc:creator>
      <dc:creator>Marchal Corrales, Juan Antonio</dc:creator>
      <dc:creator>Hackenberg, Michael</dc:creator>
      <dc:description>MiRNAs are important regulators of gene expression&#xd;
and are frequently deregulated under pathologic conditions.&#xd;
They are highly stable in bodily fluids which&#xd;
makes them feasible candidates to become minimally&#xd;
invasive biomarkers. In fact, several studies&#xd;
already proposed circulating miRNA-based biomarkers&#xd;
for different types of neoplastic, cardiovascular&#xd;
and degenerative diseases. However, many of these&#xd;
studies rely on small RNA sequencing experiments&#xd;
that are based on different RNA extraction and processing&#xd;
protocols, rendering results incomparable.&#xd;
We generated liqDB, a database for liquid biopsy&#xd;
small RNA sequencing profiles that provides users&#xd;
with meaningful information to guide their small RNA&#xd;
liquid biopsy research and to overcome technical and&#xd;
conceptual problems. By means of a user-friendly&#xd;
web interface, miRNA expression profiles from 1607&#xd;
manually annotated samples can be queried and explored&#xd;
at different levels. Result pages include downloadable&#xd;
expression matrices, differential expression&#xd;
analysis, most stably expressed miRNAs, cluster&#xd;
analysis and relevant visualizations by means of boxplots&#xd;
and heatmaps. We anticipate that liqDB will be&#xd;
a useful tool in liquid biopsy research as it provides&#xd;
a consistently annotated large compilation of experiments&#xd;
together with tools for reproducible analysis,&#xd;
comparison and hypothesis generation.</dc:description>
      <dc:date>2020-01-22T10:47:18Z</dc:date>
      <dc:date>2020-01-22T10:47:18Z</dc:date>
      <dc:date>2018-10-24</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Aparicio-Puerta, E., Jáspez, D., Lebrón, R., Koppers-Lalic, D., Marchal, J. A., &amp; Hackenberg, M. (2019). liqDB: a small-RNAseq knowledge discovery database for liquid biopsy studies. Nucleic acids research, 47(D1), D113-D120.</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/59005</dc:identifier>
      <dc:identifier>10.1093/nar/gky981</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>Oxford University Press</dc:publisher>
   </ow:Publication>
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