Thread based microfluidic platform for urinary creatinine analysis Arroyo, Manuel J. Erenas Rodríguez, Miguel María Orbe Payá, Ignacio De Dobado Jiménez, José Antonio Ballester, Pablo Blondeau, Pascal Salinas Castillo, Alfonso Capitán Vallvey, Luis Fermín Cantrell, Kevin Optical device µTAD Creatinine determination Density functional theory Calix[4]pyrrole derivative Smartphone Creatinine level in urine is a key factor to monitor kidney performance. The use of an alternative microfluidic platform based on cellulose substrates is an interesting option to integrate sample treatment, creatinine re- cognition by ionophore extraction chemistry and quantification by color measurement through consumer electronics imaging devices. The inclusion of ionophore extraction chemistry based on aryl-substituted calix[4] pyrrole synthetic receptor on 8.7 mm long cotton thread permit the sample treatment, optical recognition of creatinine and their quantification by smartphone running app in unfiltered urine samples diluted 1:100 ratio. The device shows a short response time, 30 s, to creatinine over a wide dynamic range (from 1.6× 10 6 to 5 10–2 M) with precision between 2.9–4.3%. The low interference level of representative species in urine is studied and justified by density functional theory (DFT) calculations. 2020-01-16T10:12:29Z 2020-01-16T10:12:29Z 2020-02-15 info:eu-repo/semantics/article Sensors & Actuators: B. Chemical 305 (2020) 127407 http://hdl.handle.net/10481/58810 10.1016/j.snb.2019.127407 eng info:eu-repo/semantics/openAccess Elsevier