<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/58756">
      <dc:title>Radiation and Stemness Phenotype May Influence Individual Breast Cancer Outcomes: The Crucial Role of MMPs and Microenvironment</dc:title>
      <dc:creator>Olivares Urbano, María Auxiliadora</dc:creator>
      <dc:creator>Griñán Lisón, Carmen</dc:creator>
      <dc:creator>Ríos Arrabal, Sandra</dc:creator>
      <dc:creator>Artacho Cordón, Francisco</dc:creator>
      <dc:creator>Torralbo, Ana Isabel</dc:creator>
      <dc:creator>López Ruiz, Elena</dc:creator>
      <dc:creator>Marchal Corrales, Juan Antonio</dc:creator>
      <dc:creator>Núñez Torres, María Isabel</dc:creator>
      <dc:subject>Breast cancer outcomes</dc:subject>
      <dc:subject>Cancer stem cells</dc:subject>
      <dc:subject>Stemness phenotype</dc:subject>
      <dc:subject>Matrix metalloproteases</dc:subject>
      <dc:subject>Targeted treatment</dc:subject>
      <dc:subject>Radiotherapy</dc:subject>
      <dc:subject>Irradiation</dc:subject>
      <dc:description>Breast cancer is the most common cancer in women. Radiotherapy (RT) is one of the mainstay&#xd;
treatments for cancer but in some cases is not effective. Cancer stem cells (CSCs) within the tumor&#xd;
can be responsible for recurrence and metastasis after RT. Matrix metalloproteases (MMPs), regulated&#xd;
mainly by tissue inhibitors of metalloproteinases (TIMPs) and histone deacetylases (HDACs), may&#xd;
also contribute to tumor development by modifying its activity after RT. The aim of this work was to&#xd;
study the effects of RT on the expression of MMPs, TIMPs and HDACs on different cell subpopulations&#xd;
in MCF-7, MDA-MB-231 and SK-BR-3 cell lines. We assessed the in vitro expression of these genes in&#xd;
different 3D culture models and induced tumors in female NSG mice by orthotopic xenotransplants.&#xd;
Our results showed that gene expression is related to the cell subpopulation studied, the culture&#xd;
model used and the single radiation dose administered. Moreover, the crucial role played by the&#xd;
microenvironment in terms of cell interactions and CSC plasticity in tumor growth and RT outcome is&#xd;
also shown, supporting the use of higher doses (6 Gy) to achieve better control of tumor development</dc:description>
      <dc:date>2020-01-15T08:49:09Z</dc:date>
      <dc:date>2020-01-15T08:49:09Z</dc:date>
      <dc:date>2019-11-12</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Olivares-Urbano, M. A., Griñán-Lisón, C., Ríos-Arrabal, S., Artacho-Cordón, F., Torralbo, A. I., López-Ruiz, E., ... &amp; Núñez, M. I. (2019). Radiation and Stemness Phenotype May Influence Individual Breast Cancer Outcomes: The Crucial Role of MMPs and Microenvironment. Cancers, 11(11), 1781.</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/58756</dc:identifier>
      <dc:identifier>10.3390/cancers11111781</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>