Synthesis and Characterization of a Click-Assembled 18-Atom Macrocycle That Displays Selective AXL Kinase Inhibitory Activity Cruz López, Olga María Franco Montalbán, Francisco A novel macrocyclic construct consisting of a pyrazolopyrimidine scaffold concatenated to a benzene ring through two triazoles has been developed to investigate uncharted chemical space with bioactive potential. The 18-atom macrocycle was assembled via a double copper-catalyzed alkyne−azide cycloaddition (CuAAC) reaction between 1,3- bis(azidomethyl)benzene and a bis-propargylated pyrazolo[3,4-d]pyrimidine core. The resulting macrocycle was functionalized further into a multicyclic analog that displays selective inhibitory activity against the receptor tyrosine kinase AXL. 2020-01-10T10:05:18Z 2020-01-10T10:05:18Z 2019 info:eu-repo/semantics/article Cruz-López, O., Temps, C., Longo, B., Myers, S. H., Franco-Montalban, F., & Unciti-Broceta, A. (2019). Synthesis and Characterization of a Click-Assembled 18-Atom Macrocycle That Displays Selective AXL Kinase Inhibitory Activity. ACS omega. http://hdl.handle.net/10481/58625 10.1021/acsomega.9b03525 eng http://creativecommons.org/licenses/by-nc/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial 3.0 España American Chemical Society