Muscular Fitness Mediates the Association between 25-Hydroxyvitamin D and Areal Bone Mineral Density in Children with Overweight/Obesity Gil Cosano, José Juan Gracia Marco, Luis Andrés Ubago Guisado, Esther Migueles Hidalgo, Jairo Mora González, José Rafael Escolano Margarit, María Victoria Gómez Vida, José María Maldonado Lozano, José Ortega Porcel, Francisco Bartolomé Vitamin D Strength Bone health Childhood and youth Obesity The association between vitamin D [25(OH)D] and bone health has been widely studied in children. Given that 25(OH)D and bone health are associated with muscular fitness, this could be the cornerstone to understand this relationship. Hence, the purpose of this work was to examine if the relation between 25(OH)D and areal bone mineral density (aBMD) was mediated by muscular fitness in children with overweight/obesity. Eighty-one children (8-11 years, 53 boys) with overweight/obesity were included. Body composition was measured with dual energy X-ray Absorptiometry (DXA), 25(OH)D was measured in plasma samples and muscular fitness was assessed by handgrip and standing long jump tests (averaged z-scores were used to represent overall muscular fitness). Simple mediation analyses controlling for sex, years from peak height velocity, lean mass and season were carried out. Our results showed that muscular fitness z-score, handgrip strength and standing long jump acted as mediators in the relationship between 25(OH)D and aBMD outcomes (percentages of mediation ranged from 49.6% to 68.3%). In conclusion, muscular fitness mediates the association of 25(OH)D with aBMD in children with overweight/obesity. Therefore, 25(OH)D benefits to bone health could be dependent on muscular fitness in young ages. 2020-01-09T13:45:45Z 2020-01-09T13:45:45Z 2019-11-14 info:eu-repo/semantics/article Gil-Cosano, J. J., Gracia-Marco, L., Ubago-Guisado, E., Migueles, J. H., Mora-Gonzalez, J., Escolano-Margarit, M. V., ... & Ortega, F. B. (2019). Muscular Fitness Mediates the Association between 25-Hydroxyvitamin D and Areal Bone Mineral Density in Children with Overweight/Obesity. Nutrients, 11(11), 2760. http://hdl.handle.net/10481/58579 10.3390/nu11112760 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI