Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases Ruiz Ojeda, Francisco Javier Méndez Gutiérrez, Andrea Aguilera García, Concepción María Plaza Díaz, Julio Obesity Adipose tissues Extracellular-matrix Insulin resistance The extracellular matrix (ECM) is a network of di erent proteins and proteoglycans that controls di erentiation, migration, repair, survival, and development, and it seems that its remodeling is required for healthy adipose tissue expansion. Obesity drives an excessive lipid accumulation in adipocytes, which provokes immune cells infiltration, fibrosis (an excess of deposition of ECM components such as collagens, elastin, and fibronectin) and inflammation, considered a consequence of local hypoxia, and ultimately insulin resistance. To understand the mechanism of this process is a challenge to treat the metabolic diseases. This review is focused at identifying the putative role of ECM in adipose tissue, describing its structure and components, its main tissue receptors, and how it is a ected in obesity, and subsequently the importance of an appropriate ECM remodeling in adipose tissue expansion to prevent metabolic diseases. 2019-12-05T13:00:29Z 2019-12-05T13:00:29Z 2019-10-02 info:eu-repo/semantics/article Ruiz-Ojeda, F. J., Méndez-Gutiérrez, A., Aguilera, C. M., & Plaza-Díaz, J. (2019). Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases. International Journal of Molecular Sciences, 20(19), 4888. http://hdl.handle.net/10481/58220 10.3390/ijms20194888 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI