Robust Ensemble Classification Methodology for I123-Ioflupane SPECT Images and Multiple Heterogeneous Biomarkers in the Diagnosis of Parkinson’s Disease Castillo Barnes, Diego Ramírez Pérez De Inestrosa, Javier Segovia Román, Fermín Martínez Murcia, Francisco Jesús Gorriz Sáez, Juan Manuel Machine learning Parkinson´s disease Biomarkers In last years, several approaches to develop an effective Computer-Aided-Diagnosis (CAD) system for Parkinson’s Disease (PD) have been proposed. Most of these methods have focused almost exclusively on brain images through the use of Machine-Learning algorithms suitable to characterize structural or functional patterns. Those patterns provide enough information about the status and/or the progression at intermediate and advanced stages of Parkinson’s Disease. Nevertheless this information could be insufficient at early stages of the pathology. The Parkinson’s ProgressionMarkers Initiative (PPMI) database includes neurological images along with multiple biomedical tests. This information opens up the possibility of comparing different biomarker classification results. As data come from heterogeneous sources, it is expected that we could include some of these biomarkers in order to obtain new information about the pathology. Based on that idea, this work presents an Ensemble Classification model with Performance Weighting. This proposal has been tested comparing Healthy Control subjects (HC) vs. patients with PD (considering both PD and SWEDD labeled subjects as the same class). This model combines several Support-Vector-Machine (SVM) with linear kernel classifiers for different biomedical group of tests—including CerebroSpinal Fluid (CSF), RNA, and Serum tests—and pre-processed neuroimages features (Voxels-As-Features and a list of definedMorphological Features) fromPPMI database subjects. The proposed methodology makes use of all data sources and selects the most discriminant features (mainly from neuroimages). Using this performance-weighted ensemble classification model, classification results up to 96% were obtained. 2019-11-18T12:19:17Z 2019-11-18T12:19:17Z 2018-08-14 info:eu-repo/semantics/article Castillo-Barnes D, Ramírez J, Segovia F, Martínez-Murcia FJ, Salas-Gonzalez D and Górriz JM (2018) Robust Ensemble Classification Methodology for I123-Ioflupane SPECT Images and Multiple Heterogeneous Biomarkers in the Diagnosis of Parkinson’s Disease. Front. Neuroinform. 12:53. http://hdl.handle.net/10481/57957 10.3389/fninf.2018.00053 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Frontiers Media