The Parkinson’s Disease Mendelian Randomization Research Portal Noyce, Alastair Brandes Ciga, Sara Durán Ogalla, Raquel Mendelian randomization Parkinson´s disease Public resource Risk factor Mendelian randomization is a method for exploring observational associations to find evidence of causality. To apply Mendelian randomization between risk factors/phenotypic traits (exposures) and PD in a large, unbiased manner, and to create a public resource for research. We observed evidence for causal associations between 12 exposures and risk of PD. Of these, nine were effects related to increasing adiposity and decreasing risk of PD. The remaining top three exposures that affected PD risk were tea drinking, time spent watching television, and forced vital capacity, but these may have been biased and were less convincing. Other exposures at nominal statistical significance included inverse effects of smoking and alcohol. We present a new platform which offers Mendelian randomization analyses for a total of 5,839 genome-wide association studies versus the largest PD genome-wide association studies available (https://pdgenetics.shinyapps.io/MRportal/). Alongside, we report further evidence to support a causal role for adiposity on lowering the risk of PD. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. 2019-11-15T12:46:36Z 2019-11-15T12:46:36Z 2019 info:eu-repo/semantics/article Noyce, A., Ciga, S. B., Kim, J., Heilbron, K., Hemani, G., Xue, A., ... & Blauwendraat, C. (2019). The Parkinsons Disease Mendelian Randomization Research Portal. BioRxiv, 604033. http://hdl.handle.net/10481/57927 10.1002/mds.27873 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Wiley