Stay Fit, Stay Young: Mitochondria in Movement: The Role of Exercise in the New Mitochondrial Paradigm Rodríguez Huertas, Jesús Francisco Casuso, Rafael A. Hernansanz Agustín, Pablo Cogliati, Sara Skeletal muscles require the proper production and distribution of energy to sustain their work. To ensure this requirement is met, mitochondria form large networks within skeletal muscle cells, and during exercise, they can enhance their functions. In the present review, we discuss recent findings on exercise-induced mitochondrial adaptations. We emphasize the importance of mitochondrial biogenesis, morphological changes, and increases in respiratory supercomplex formation as mechanisms triggered by exercise that may increase the function of skeletal muscles. Finally, we highlight the possible effects of nutraceutical compounds on mitochondrial performance during exercise and outline the use of exercise as a therapeutic tool in noncommunicable disease prevention. The resulting picture shows that the modulation of mitochondrial activity by exercise is not only fundamental for physical performance but also a key point for whole-organism well-being. 2019-11-15T11:12:17Z 2019-11-15T11:12:17Z 2019-06-19 info:eu-repo/semantics/article Huertas, J. R., Casuso, R. A., Agustín, P. H., & Cogliati, S. (2019). Stay Fit, Stay Young: Mitochondria in Movement: The Role of Exercise in the New Mitochondrial Paradigm. Oxidative Medicine and Cellular Longevity, 2019. http://hdl.handle.net/10481/57916 10.1155/2019/7058350 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Hindawi