Biofunctionalization with a TGFβ-1 Inhibitor Peptide in the Osseointegration of Synthetic Bone Grafts: An In Vivo Study in Beagle Dogs Cirera, Andrea Manzanares, María Cristina Sevilla, Pablo Ortiz Hernández, Mónica Galindo Moreno, Pablo Antonio Gil, Javier Osseointegration Biofunctionalization Histomorphometrical analysis Scanning electron microscopy Synthetic bone graft TGFbeta- 1 Objectives: The aim of this research was to determine the osseointegration of two presentations of biphasic calcium phosphate (BCP) biomaterial—one untreated and another submitted to biofunctionalization with a TGF- 1 inhibitor peptide, P144, on dental alveolus. The biofunctionalization of the biomaterial’s granules maintains a stable membranous bone formation throughout the experiment timeline, benefitting from the constant presence of vascular structures in the alveolar space, in a more active manner that in the control samples. Better results in the experimental groups were proven both by quantitative and qualitative analysis. Synthetic bone graft biofunctionalization results in slightly better quantitative parameters of the implant’s osseointegration. The qualitative histological and ultramicroscopic analysis shows that biofunctionalization may shorten the healing period of dental biomaterials. 2019-11-15T09:32:45Z 2019-11-15T09:32:45Z 2019-09-27 info:eu-repo/semantics/article Cirera, A., Manzanares, M. C., Sevilla, P., Ortiz-Hernandez, M., Galindo-Moreno, P., & Gil, J. (2019). Biofunctionalization with a TGFβ-1 inhibitor peptide in the osseointegration of synthetic bone grafts: an in vivo study in beagle dogs. Materials, 12(19), 3168. http://hdl.handle.net/10481/57912 10.3390/ma12193168 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI