Visual evoked potentials in offspring born to mothers with overweight, obesity and gestational diabetes Torres Espinola, Francisco Jose Berglund, Staffan K. García García, Salomé Pérez García, Miguel Catena Martínez, Andrés Rueda Valdivia, Ricardo Sáez, Jose Antonio Campoy Folgoso, Cristina Overweight, obesity, and gestational diabetes (GD) during pregnancy may negatively affect neurodevelopment in the offspring. However, the mechanisms are unclear and objective measures of neurodevelopment in infancy are scarce. We hypothesized that these maternal metabolic pathologies impair cortical visual evoked potentials (cVEPs), a proxy for visual and neuronal maturity. At 3 months of age, visual acuity was significantly poorer in offspring born to GD mothers. At 18 months of age, there were no differences in visual acuity but infants born to GD mothers had significantly longer latencies of cVEPs when measured at 15', and 30' of arc. The group differences at 30' remained significant after confounder adjustment (mean [SD] 121.0 [16.0] vs. 112.6 [7.6] ms in controls, p = 0.007) and the most prolonged latencies were observed in offspring to GD mothers with concurrent overweight (128.9 [26.9] ms, p = 0.002) and obesity (118.5 [5.1] ms, p = 0.020). Infants born to mothers with GD, particularly those with concurrent overweight or obesity, have prolonged latencies of visual evoked potentials at 18 months of age, suggesting that this maternal metabolic profile have a long lasting, non-optimal, effect on infants brain development. 2019-11-13T11:40:13Z 2019-11-13T11:40:13Z 2018-09-12 journal article Torres-EspõÂnola FJ, Berglund SK, GarcõÂa S, PeÂrez-GarcõÂa M, Catena A, Rueda R, et al. (2018) Visual evoked potentials in offspring born to mothers with overweight, obesity and gestational diabetes. PLoS ONE 13(9): e0203754. http://hdl.handle.net/10481/57863 10.1371/journal.pone.0203754 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España PLOS