<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/57580">
      <dc:title>Klotho and Aminopeptidases as Early Biomarkers of Renal Injury in Zucker Obese Rats</dc:title>
      <dc:creator>Montoro-Molina, Sebastián</dc:creator>
      <dc:creator>López Carmona, Antonio</dc:creator>
      <dc:creator>Quesada, Andrés</dc:creator>
      <dc:creator>O'Valle Ravassa, Francisco Javier</dc:creator>
      <dc:creator>Martín Morales, Natividad</dc:creator>
      <dc:creator>Osuna Ortega, Antonio</dc:creator>
      <dc:creator>Vargas, Félix</dc:creator>
      <dc:creator>Wangensteen, Rosemary</dc:creator>
      <dc:subject>Zucker rats</dc:subject>
      <dc:subject>Aminopeptidases</dc:subject>
      <dc:subject>Klotho</dc:subject>
      <dc:subject>Hydroxyproline</dc:subject>
      <dc:subject>Renal injury</dc:subject>
      <dc:description>The aim of this study was to investigate if urinary glutamyl aminopeptidase (GluAp),&#xd;
alanyl aminopeptidase (AlaAp), Klotho and hydroxyproline can be considered as&#xd;
potential biomarkers of renal injury and fibrosis in an experimental model of obesity.&#xd;
Male Zucker lean (ZL) and obese (ZO) rats were studied from 2 to 8 months old.&#xd;
Kidneys from ZO rats at the end of the study (8 months old) developed mild focal&#xd;
and segmental glomerulosclerosis as well as moderate tubulointerstitial injury. Urinary&#xd;
excretion of Klotho was higher in ZO rats at 2, 5, and 8 months of study, plasma&#xd;
Klotho levels were reduced and protein abundance of Klotho in renal tissue was similar&#xd;
in ZL and ZO rats. GluAp and AlaAp urinary activities were also increased in ZO rats&#xd;
throughout the time-course study. ZO rats showed an augmentation of hydroxyproline&#xd;
content in renal tissue and a significant increase of tubulointerstitial fibrosis. Correlation&#xd;
studies demonstrated that GluAp, AlaAp, and Klotho are early diagnostic markers of&#xd;
renal lesions in Zucker obese rats. Proteinuria and hydroxyproline can be considered&#xd;
delayed diagnostic markers because their contribution to diagnosis starts later. Another&#xd;
relevant result is that GluAp, AlaAp, and Klotho are related not only with diagnosis but&#xd;
also with prognosis of renal lesions in Zucker obese rats.</dc:description>
      <dc:date>2019-10-29T11:05:20Z</dc:date>
      <dc:date>2019-10-29T11:05:20Z</dc:date>
      <dc:date>2018-11-13</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Montoro-Molina S, López-Carmona A, Quesada A, O’Valle F, Martín-Morales N, Osuna A, Vargas F and Wangensteen R (2018) Klotho and Aminopeptidases as Early Biomarkers of Renal Injury in Zucker Obese Rats. Front. Physiol. 9:1599.</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/57580</dc:identifier>
      <dc:identifier>10.3389/fphys.2018.01599</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>Frontiers Media</dc:publisher>
   </ow:Publication>
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