Effect of mistimed eating patterns on breast and prostate cancer risk (MCC-Spain Study) Kogevinas, Manolis Jiménez Moleón, José Juan Breast cancer Prostate cancer Circadian disruption Diet Modern life involves mistimed sleeping and eating patterns that in experimental studies are associated with adverse health effects. We assessed whether timing of meals is associated with breast and prostate cancer risk taking into account lifestyle and chronotype, a characteristic correlating with preference for morning or evening activity. We conducted a population-based case-control study in Spain, 2008–2013. In this analysis we included 621 cases of prostate and 1,205 of breast cancer and 872 male and 1,321 female population controls who had never worked night shift. Subjects were interviewed on timing of meals, sleep and chronotype and completed a Food Frequency Questionaire. Adherence to the World Cancer Research Fund/ American Institute of Cancer Research recommendations for cancer prevention was examined. Compared with subjects sleeping immediately after supper, those sleeping two or more hours after supper had a 20% reduction in cancer risk for breast and prostate cancer combined (adjusted Odds Ratio [OR]50.80, 95%CI 0.67–0.96) and in each cancer individually (prostate cancer OR50.74, 0.55–0.99; breast cancer OR50.84, 0.67–1.06). A similar protection was observed in subjects having supper before 9 pm compared with supper after 10 pm. The effect of longer supper-sleep interval was more pronounced among subjects adhering to cancer prevention recommendations (OR both cancers5 0.65, 0.44–0.97) and in morning types (OR both cancers50.66, 0.49–0.90). Adherence to diurnal eating patterns and specifically a long interval between last meal and sleep are associated with a lower cancer risk, stressing the importance of evaluating timing in studies on diet and cancer. 2019-10-29T10:30:12Z 2019-10-29T10:30:12Z 2018-07-17 journal article Kogevinas, M., Espinosa, A., Castelló, A., Gómez‐Acebo, I., Guevara, M., Martin, V., ... & Costas, L. (2018). Effect of mistimed eating patterns on breast and prostate cancer risk (MCC‐Spain Study). International journal of cancer, 143(10), 2380-2389. http://hdl.handle.net/10481/57574 10.1002/ijc.31649 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access Atribución-NoComercial-SinDerivadas 3.0 España Wiley