Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts Verdejo Román, Juan Torres Espinola, Francisco Jose Campos, Daniel Campoy Folgoso, Cristina Prepregnancy maternal obesity is a global health problem and has been associated with offspring metabolic and mental ill-health. However, there is a knowledge gap in understanding potential neurobiological factors related to these associations. This study explored the relation between maternal prepregnancy body mass index (BMI) and offspring brain white matter microstructure at the age of 6, 10, and 26 years in three independent cohorts. Maternal BMI was associated with higher FA and lower MD in multiple brain tracts in offspring aged 10 and 26 years, but not at 6 years of age. Future studies should examine whether our observations can be replicated and explore the potential causal nature of the findings. 2019-10-23T08:24:25Z 2019-10-23T08:24:25Z 2019 journal article Verdejo-Román, J., Björnholm, L., Muetzel, R.L. et al. Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts. Int J Obes 43, 1995–2006 (2019). [https://doi.org/10.1038/s41366-018-0268-x] http://hdl.handle.net/10481/57469 10.1038/s41366-018-0268-x eng info:eu-repo/grantAgreement/EC/FP7/633595 DynaHEALTH info:eu-repo/grantAgreement/EC/FP7/733206 LifeCycle http://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access Atribución-NoComercial-SinDerivadas 3.0 España Springer Nature