<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/57373">
      <dc:title>Evaluation of the overdiagnosis in breast screening programmes using a Monte Carlo simulation tool: a study of the influence of the parameters defining the programme configuration</dc:title>
      <dc:creator>Forastero, Cristina</dc:creator>
      <dc:creator>Zamora, Luis</dc:creator>
      <dc:creator>Guirado, Damián</dc:creator>
      <dc:creator>Lallena Rojo, Antonio Miguel</dc:creator>
      <dc:description>Objectives To build up and test a Monte Carlo simulation&#xd;
procedure for the investigation of overdiagnosis in breast&#xd;
screening programmes (BSPs).&#xd;
Design A Monte Carlo tool previously developed has been&#xd;
adapted for obtaining the quantities of interest in order to&#xd;
determine the overdiagnosis: the annual and cumulative&#xd;
number of cancers detected by screening, plus interval&#xd;
cancers, for a population following the BSP, and detected&#xd;
clinically for the same population in the absence of&#xd;
screening. Overdiagnosis is obtained by comparing these&#xd;
results in a direct way.&#xd;
Results Overdiagnosis between 7% and 20%, depending&#xd;
on the specific configuration of the programme, have been&#xd;
found. These range of values is in agreement with some of&#xd;
the results available for actual BSPs. In the cases analysed,&#xd;
a reduction of 11% at most has been found in the number&#xd;
of invasive tumours detected by screening in comparison&#xd;
to those clinically detected in the control population. It has&#xd;
been possible to establish that overdiagnosis is almost&#xd;
entirely linked to ductal carcinoma in situ tumours.&#xd;
Conclusions The use of Monte Carlo tools may facilitate&#xd;
the analysis of overdiagnosis in actual BSPs, permitting to&#xd;
address the role played by various quantities of relevance&#xd;
for them.</dc:description>
      <dc:date>2019-10-16T08:41:14Z</dc:date>
      <dc:date>2019-10-16T08:41:14Z</dc:date>
      <dc:date>2019</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Forastero C, Zamora LI, Guirado D, et al. Evaluation of the overdiagnosis in breast screening programmes using a Monte Carlo simulation tool: a study of the influence of the parameters defining the programme configuration. BMJ Open 2019;9:e023187.</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/57373</dc:identifier>
      <dc:identifier>10.1136/ bmjopen-2018-023187</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc/3.0/es/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License</dc:rights>
      <dc:rights>Atribución-NoComercial 3.0 España</dc:rights>
      <dc:publisher>BMJ Open</dc:publisher>
   </ow:Publication>
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