Parkinson’s Disease Detection Using Isosurfaces-Based Features and Convolutional Neural Networks Ortiz, Andrés Munilla, Jorge Martínez Íbañez, Manuel Gorriz Sáez, Juan Manuel Ramírez Pérez De Inestrosa, Javier Salas-González, Diego Deep learning isosurfaces Parkinson´s disease Convolutional neural networks computer-aided diagnosis Computer aided diagnosis systems based on brain imaging are an important tool to assist in the diagnosis of Parkinson’s disease, whose ultimate goal is the detection by automatic recognizing of patterns that characterize the disease. In recent times Convolutional Neural Networks (CNN) have proved to be amazingly useful for that task. The drawback, however, is that 3D brain images contain a huge amount of information that leads to complex CNN architectures. When these architectures become too complex, classification performances often degrades because the limitations of the training algorithm and overfitting. Thus, this paper proposes the use of isosurfaces as a way to reduce such amount of data while keeping the most relevant information. These isosurfaces are then used to implement a classification system which uses two of the most well-known CNN architectures, LeNet and AlexNet, to classify DaTScan images with an average accuracy of 95.1% and AUC = 97%, obtaining comparable (slightly better) values to those obtained for most of the recently proposed systems. It can be concluded therefore that the computation of isosurfaces reduces the complexity of the inputs significantly, resulting in high classification accuracies with reduced computational burden. 2019-10-15T08:43:20Z 2019-10-15T08:43:20Z 2019-07-02 journal article Ortiz A, Munilla J, Martínez-Ibañez M, Górriz JM, Ramírez J and Salas-Gonzalez D (2019) Parkinson’s Disease Detection Using Isosurfaces-Based Features and Convolutional Neural Networks. Front. Neuroinform. 13:48 http://hdl.handle.net/10481/57351 10.3389/fninf.2019.00048 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España Frontiers in Neuroinformatics