<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/57350">
      <dc:title>Hearing regeneration and regenerative medicine: present and future approaches</dc:title>
      <dc:creator>Nacher Soler, German</dc:creator>
      <dc:creator>Garrido, Jose Manuel</dc:creator>
      <dc:creator>Rodríguez Serrano, Fernando</dc:creator>
      <dc:subject>Stem cell therapy</dc:subject>
      <dc:subject>hearing regeneration</dc:subject>
      <dc:subject>hair cell</dc:subject>
      <dc:subject>spiral ganglion neuron</dc:subject>
      <dc:subject>ribbon synapse</dc:subject>
      <dc:description>More than 5% of the world population lives with a hearing impairment. The&#xd;
main factors responsible for hearing degeneration are ototoxic drugs, aging,&#xd;
continued exposure to excessive noise and infections. The pool of adult stem&#xd;
cells in the inner ear drops dramatically after birth, and therefore an endogenous&#xd;
cellular source for regeneration is absent. Hearing loss can emerge&#xd;
after the degeneration of different cochlear components, so there are multiple&#xd;
targets to be reached, such as hair cells (HCs), spiral ganglion neurons&#xd;
(SGNs), supporting cells (SCs) and ribbon synapses. Important discoveries in&#xd;
the hearing regeneration field have been reported regarding stem cell transplantation,&#xd;
migration and survival; genetic systems for cell fate monitoring;&#xd;
and stem cell differentiation to HCs, SGNs and SCs using adult stem cells,&#xd;
embryonic stem cells and induced pluripotent stem cells. Moreover, some&#xd;
molecular mediators that affect the establishment of functional synapses&#xd;
have been identified. In this review, we will focus on reporting the state of&#xd;
the art in the regenerative medicine field for hearing recovery. Stem cell&#xd;
research has enabled remarkable advances in regeneration, particularly in&#xd;
neuronal cells and synapses. Despite the progress achieved, there are certain&#xd;
issues that need a deeper development to improve the results already&#xd;
obtained, or to develop new approaches aiming for the clinical application.</dc:description>
      <dc:date>2019-10-15T08:35:44Z</dc:date>
      <dc:date>2019-10-15T08:35:44Z</dc:date>
      <dc:date>2019</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Nacher-Soler, G., Garrido, J.,  &amp; Rodríguez-Serrano, F. (2019). Hearing regeneration and regenerative medicine: present and future approaches. Archives of Medical Science, 15(4), 957-967</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/57350</dc:identifier>
      <dc:identifier>10.5114/aoms.2019.86062</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-sa/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución-NoComercial-CompartirIgual 3.0 España</dc:rights>
      <dc:publisher>Archives of Medical Science</dc:publisher>
   </ow:Publication>
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