<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/55769">
      <dc:title>Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study</dc:title>
      <dc:creator>Vitelli Storelli, Facundo</dc:creator>
      <dc:creator>Olmedo Requena, María Rocío</dc:creator>
      <dc:subject>Flavonoids</dc:subject>
      <dc:subject>Intake</dc:subject>
      <dc:subject>Gastric cancer</dc:subject>
      <dc:subject>Case-control study</dc:subject>
      <dc:subject>MCC-Spain</dc:subject>
      <dc:description>Several epidemiological studies have investigated the association between the dietary&#xd;
flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating&#xd;
the relationship between the different classes of flavonoids and the histological types and origin of&#xd;
GC can be of interest to the research community. We used data from a population-based multi-case&#xd;
control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC&#xd;
cases were included in this study. Odds ratios (ORs) were calculated using the mixed e ects logistic&#xd;
regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated&#xd;
with a lower GC risk (ORlog2 = 0.76; 95% CI = 0.65–0.89; ORq4vsq1 = 0.60; 95%CI = 0.40–0.89;&#xd;
ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins,&#xd;
chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with&#xd;
higher cancer risk, but without reaching a statistical significance. In general, no differences were&#xd;
observed in the GC risk according to the location and histological type. The flavonoid intake seems&#xd;
to be a protective factor against GC within the MCC-study. This effect may vary depending on the&#xd;
flavonoid class but not by the histological type and location of the tumor. Broader studies with larger&#xd;
sample size and greater geographical variability are necessary.</dc:description>
      <dc:date>2019-05-18T22:39:15Z</dc:date>
      <dc:date>2019-05-18T22:39:15Z</dc:date>
      <dc:date>2019-04-27</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Olmedo-Requena, R.[et al.]. Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study. Nutrients 2019, 11, 967; doi:10.3390/nu11050967.</dc:identifier>
      <dc:identifier>2072-6643</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/55769</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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