<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/55760">
      <dc:title>The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity</dc:title>
      <dc:creator>Cerdó, Tomás</dc:creator>
      <dc:creator>García Santos, José Antonio</dc:creator>
      <dc:creator>G. Bermúdez, Mercedes</dc:creator>
      <dc:creator>Campoy Folgoso, Cristina</dc:creator>
      <dc:subject>Obesity</dc:subject>
      <dc:subject>Gut microbiota</dc:subject>
      <dc:subject>Probiotics</dc:subject>
      <dc:subject>Prebiotics</dc:subject>
      <dc:subject>Nutrition</dc:subject>
      <dc:description>Obesity is a global pandemic complex to treat due to its multifactorial pathogenesis—an&#xd;
unhealthy lifestyle, neuronal and hormonal mechanisms, and genetic and epigenetic factors are&#xd;
involved. Scientific evidence supports the idea that obesity and metabolic consequences are strongly&#xd;
related to changes in both the function and composition of gut microbiota, which exert an essential role&#xd;
in modulating energy metabolism. Modifications of gut microbiota composition have been associated&#xd;
with variations in body weight and body mass index. Lifestyle modifications remain as primary&#xd;
therapy for obesity and related metabolic disorders. New therapeutic strategies to treat/prevent&#xd;
obesity have been proposed, based on pre- and/or probiotic modulation of gut microbiota to mimic&#xd;
that found in healthy non-obese subjects. Based on human and animal studies, this review aimed&#xd;
to discuss mechanisms through which gut microbiota could act as a key modifier of obesity and&#xd;
related metabolic complications. Evidence from animal studies and human clinical trials suggesting&#xd;
potential beneficial effects of prebiotic and various probiotic strains on those physical, biochemical,&#xd;
and metabolic parameters related to obesity is presented. As a conclusion, a deeper knowledge&#xd;
about pre-/probiotic mechanisms of action, in combination with adequately powered, randomized&#xd;
controlled follow-up studies, will facilitate the clinical application and development of personalized&#xd;
healthcare strategies.</dc:description>
      <dc:date>2019-05-18T20:45:48Z</dc:date>
      <dc:date>2019-05-18T20:45:48Z</dc:date>
      <dc:date>2019-03-15</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Cerdó, T. [et al.]. The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity. Nutrients 2019, 11, 635; doi:10.3390/nu11030635.</dc:identifier>
      <dc:identifier>2072-6643</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/55760</dc:identifier>
      <dc:identifier>10.3390/nu11030635</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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