Recent Progress in Gene Therapy for Ovarian Cancer Áyen, Ángela Jiménez Martínez, Yaiza Marchal Corrales, Juan Antonio Boulaiz Tassi, Houria Ovarian cancer Gene therapy Delivery systems Promoter Suicide genes Ovarian cancer stem cells Ovarian cancer is the most lethal gynecological malignancy in developed countries. This is due to the lack of specific symptoms that hinder early diagnosis and to the high relapse rate after treatment with radical surgery and chemotherapy. Hence, novel therapeutic modalities to improve clinical outcomes in ovarian malignancy are needed. Progress in gene therapy has allowed the development of several strategies against ovarian cancer. Most are focused on the design of improved vectors to enhance gene delivery on the one hand, and, on the other hand, on the development of new therapeutic tools based on the restoration or destruction of a deregulated gene, the use of suicide genes, genetic immunopotentiation, the inhibition of tumour angiogenesis, the alteration of pharmacological resistance, and oncolytic virotherapy. In the present manuscript, we review the recent advances made in gene therapy for ovarian cancer, highlighting the latest clinical trials experience, the current challenges and future perspectives. 2019-04-04T11:41:04Z 2019-04-04T11:41:04Z 2018-06-30 info:eu-repo/semantics/article Áyen, Á. [et al.]. Recent Progress in Gene Therapy for Ovarian Cancer. Int. J. Mol. Sci. 2018, 19, 1930; doi:10.3390/ijms19071930. 1422-0067 http://hdl.handle.net/10481/55342 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI