Psychiatric Comorbidity in Children and Adults with Gluten-Related Disorders: A Narrative Review Slim, Mahmoud Rico-Villademoros, Fernando Calandre, Elena P. Celiac disease Non-celiac gluten sensitivity Psychiatric disorders Depression Anxiety disorders Eating disorders ADHD Autism Psychosis Gluten-related disorders are characterized by both intestinal and extraintestinal manifestations. Previous studies have suggested an association between gluten-related disorder and psychiatric comorbidities. The objective of our current review is to provide a comprehensive review of this association in children and adults. A systematic literature search using MEDLINE, Embase and PsycINFO from inception to 2018 using terms of ‘celiac disease’ or ‘gluten-sensitivity-related disorders’ combined with terms of ‘mental disorders’ was conducted. A total of 47 articles were included in our review, of which 28 studies were conducted in adults, 11 studies in children and eight studies included both children and adults. The majority of studies were conducted in celiac disease, two studies in non-celiac gluten sensitivity and none in wheat allergy. Enough evidence is currently available supporting the association of celiac disease with depression and, to a lesser extent, with eating disorders. Further investigation is warranted to evaluate the association suggested with other psychiatric disorders. In conclusion, routine surveillance of potential psychiatric manifestations in children and adults with gluten-related disorders should be carried out by the attending physician. 2019-03-12T13:30:48Z 2019-03-12T13:30:48Z 2018-07-06 journal article Slim, M.; Rico-Villademoros, F.; Calandre, E. Psychiatric Comorbidity in Children and Adults with Gluten-Related Disorders: A Narrative Review. Nutrients 2018, 10, 875. 2072-6643 http://hdl.handle.net/10481/54957 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI