Metallofluorescent Nanoparticles for Multimodal Applications Delgado-Gonzalez, Antonio García-Fernández, Emilio Valero, Teresa Cano-Cortés, Victoria Ruedas Rama, María José Unciti-Broceta, Asier Sánchez Martín, Rosario María Díaz Mochón, Juan José Orte Gutiérrez, Ángel Herein, we describe the synthesis and application of cross-linked polystyrene-based dual-function nano- and microparticles containing both fluorescent tags and metals. Despite containing a single dye, these particles exhibit a characteristic dual-band fluorescence emission. Moreover, these particles can be combined with different metal ions to obtain hybrid metallofluorescent particles. We demonstrate that these particles are easily nanofected into living cells, allowing them to be used for effective fingerprinting in multimodal fluorescence-based and mass spectrometry-based flow cytometry experiments. Likewise, the in situ reductions of the metal ions enable other potential uses of the particles as heterogeneous catalysts. 2018-06-04T11:26:31Z 2018-06-04T11:26:31Z 2018-01-05 journal article Delgado-Gonzalez, Antonio; et. al. Metallofluorescent Nanoparticles for Multimodal Applications. ACS Omega 2018, 3, 144−153 [http://hdl.handle.net/10481/51224] http://hdl.handle.net/10481/51224 10.1021/acsomega.7b01984 eng http://creativecommons.org/licenses/by-nc/3.0/es/ open access Atribución-NoComercial 3.0 España American Chemical Society