<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/50334">
      <dc:title>Improved reactive nanoparticles to treat dentin hypersensitivity.</dc:title>
      <dc:creator>Toledano Osorio, Manuel</dc:creator>
      <dc:creator>Osorio Ruiz, María Estrella</dc:creator>
      <dc:creator>Sánchez Aguilera, Fátima</dc:creator>
      <dc:creator>Medina Castillo, Antonio Luis</dc:creator>
      <dc:creator>Osorio Ruiz, Raquel</dc:creator>
      <dc:creator>Toledano Pérez, Manuel</dc:creator>
      <dc:subject>cervical dentin</dc:subject>
      <dc:subject>hypersensitivity</dc:subject>
      <dc:subject>DMA</dc:subject>
      <dc:subject>nanoparticles</dc:subject>
      <dc:description>The aim of this study was to evaluate the effectiveness of different nanoparticles-based solutions for dentin permeability reduction and to determine the viscoelastic performance of cervical dentin after their application. Four experimental nanoparticle solutions based on zinc, calcium or doxycycline-loaded polymeric nanoparticles (NPs) were applied on citric acid etched dentin, to facilitate the occlusion and the reduction of the fluid flow at the dentinal tubules.  After 24 h and 7 d of storage, cervical dentin was evaluated for fluid filtration. Field emission scanning electron microscopy, energy dispersive analysis, AFM and Nano-DMA analysis were also performed. Complex, storage, loss modulus and tan delta (δ) were assessed. Doxycycline-loaded NPs impaired tubule occlusion and fluid flow reduction trough dentin. Tubules were 100% occluded in dentin treated with calcium-loaded NPs or zinc-loaded NPs, analyzed at 7 d. Dentin treated with both zinc-NPs and calcium-NPs attained the highest reduction of dentinal fluid flow. Moreover, when treating dentin with zinc-NPs, complex modulus values attained at intertubular and peritubular dentin were higher than those obtained after applying calcium-NPs. Zinc-NPs are then supposed to fasten active dentin remodeling, with increased maturity and high mechanical properties. Zinc-based nanoparticles are then proposed for effective dentin remineralization and tubular occlusion. Further research to finally prove for clinical benefits in patients with dentin hypersensitivity using Zn-doped nanoparticles is encouraged.</dc:description>
      <dc:date>2018-04-20T08:38:01Z</dc:date>
      <dc:date>2018-04-20T08:38:01Z</dc:date>
      <dc:date>2018-03</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Toledano-Osorio M, Osorio E, Aguilera FS, Luis Medina-Castillo A, Toledano M,  Osorio R. Improved reactive nanoparticles to treat dentin hypersensitivity. Acta  Biomater. 2018 Mar 24. pii: S1742-7061(18)30164-8 [ http://hdl.handle.net/10481/50334]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/50334</dc:identifier>
      <dc:identifier>10.1016/j.actbio.2018.03.033.</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/3.0/es/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución-NoComercial-SinDerivadas 3.0 España</dc:rights>
   </ow:Publication>
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