Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts Gasparrini, Massimiliano Forbes Hernández, Tamara Yuliett Giampieri, Francesca Afrin, Sadia Mezzetti, Bruno Quiles Morales, José Luis Bompadre, Stefano Battino, Maurizio Strawberry LPS Oxidative stress Inflammation Prevention A protracted pro-inflammatory state is a major contributing factor in the development, progression and complication of the most common chronic pathologies. Fruit and vegetables represent the main sources of dietary antioxidants and their consumption can be considered an efficient tool to counteract inflammatory states. In this context an evaluation of the protective effects of strawberry extracts on inflammatory stress induced by E. coli LPS on human dermal fibroblast cells was performed in terms of viability assays, ROS and nitrite production and biomarkers of oxidative damage of the main biological macromolecules. The results demonstrated that strawberry extracts exerted an anti-inflammatory effect on LPS-treated cells, through an increase in cell viability, and the reduction of ROS and nitrite levels, and lipid, protein and DNA damage. This work showed for the first time the potential health benefits of strawberry extract against inflammatory and oxidative stress in LPS-treated human dermal fibroblast cells. 2018-01-24T13:04:21Z 2018-01-24T13:04:21Z 2016-12-30 journal article Gasparrini. M; et al. Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts. Molecules, 22(1): 164 (2017). [http://hdl.handle.net/10481/49154] 1420-3049 http://hdl.handle.net/10481/49154 10.3390/molecules22010164 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ open access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License MDPI