Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer Conde Muíño, Raquel Cuadros Celorrio, Marta Eugenia Zambudio, Natalia Segura-Jiménez, Inmaculada Cano Gutiérrez, Carlos Palma Carazo, Pablo Biomarkers Chemoradiation Rectal Cancer There has been a high local recurrence rate in rectal cancer. Besides improvements in surgical techniques, both neoadjuvant short-course radiotherapy and long-course chemoradiation improve oncological results. Approximately 40–60% of rectal cancer patients treated with neoadjuvant chemoradiation achieve some degree of pathologic response. However, there is no effective method of predicting which patients will respond to neoadjuvant treatment. Recent studies have evaluated the potential of genetic biomarkers to predict outcome in locally advanced rectal adenocarcinoma treated with neoadjuvant chemoradiation. The articles produced by the PubMed search were reviewed for those specifically addressing a genetic profile’s ability to predict response to neoadjuvant treatment in rectal cancer. Although tissue gene microarray profiling has led to promising data in cancer, to date, none of the identified signatures or molecular markers in locally advanced rectal cancer has been successfully validated as a diagnostic or prognostic tool applicable to routine clinical practice. 2015-12-14T12:03:45Z 2015-12-14T12:03:45Z 2015 info:eu-repo/semantics/article Conde-Muíño, R.; et al. Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer. BioMed Research International, 2015: 921435 (2015). [http://hdl.handle.net/10481/39198] 2314-6133 2314-6141 http://hdl.handle.net/10481/39198 10.1155/2015/921435 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ info:eu-repo/semantics/openAccess Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Hindawi Publishing Corporation