Bone Regeneration from PLGA Micro-Nanoparticles Ortega-Oller, Inmaculada Padial Molina, Miguel Galindo Moreno, Pablo Antonio O'Valle Ravassa, Francisco Javier Jódar Reyes, Ana Belén Peula-García, José Manuel Bone regeneration Poly-lactic-co-glycolic (PLGA) Synthetic polymers Biomolecules Poly-lactic-co-glycolic acid (PLGA) is one of the most widely used synthetic polymers for development of delivery systems for drugs and therapeutic biomolecules and as component of tissue engineering applications. Its properties and versatility allow it to be a reference polymer in manufacturing of nano- and microparticles to encapsulate and deliver a wide variety of hydrophobic and hydrophilic molecules. It additionally facilitates and extends its use to encapsulate biomolecules such as proteins or nucleic acids that can be released in a controlled way. This review focuses on the use of nano/microparticles of PLGA as a delivery system of one of the most commonly used growth factors in bone tissue engineering, the bone morphogenetic protein 2 (BMP2). Thus, all the needed requirements to reach a controlled delivery of BMP2 using PLGA particles as a main component have been examined. The problems and solutions for the adequate development of this system with a great potential in cell differentiation and proliferation processes under a bone regenerative point of view are discussed. 2015-12-09T13:21:40Z 2015-12-09T13:21:40Z 2015 info:eu-repo/semantics/article Ortega-Oller, I.; et al. Bone Regeneration from PLGA Micro-Nanoparticles. BioMed Research International, 2015: 415289 (2015). [http://hdl.handle.net/10481/39135] 2314-6133 2314-6141 http://hdl.handle.net/10481/39135 10.1155/2015/415289 eng info:eu-repo/grantAgreement/EC/FP7/291780 info:eu-repo/semantics/openAccess Hindawi Publishing Corporation