Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases Rojo, David Hevia, Arancha Bargiela, Rafael López, Patricia Cuervo, Adriana González, Sonia Suárez, Ana Sánchez, Borja Martínez-Martínez, Mónica Milani, Christian Ventura, Marco Barbas, Coral Moya, Andrés Suárez García, Antonio Margolles, Abelardo Ferrer, Manuel Autoimmunity Microbiome Obesity Multiple factors have been shown to alter intestinal microbial diversity. It remains to be seen, however, how multiple collective pressures impact the activity in the gut environment and which, if any, is positioned as a dominant driving factor determining the final metabolic outcomes. Here, we describe the results of a metabolome-wide scan of gut microbiota in 18 subjects with systemic lupus erythematosus (SLE) and 17 healthy control subjects and demonstrate a statistically significant difference (p < 0.05) between the two groups. Healthy controls could be categorized (p < 0.05) based on their body mass index (BMI), whereas individuals with SLE could not. We discuss the prevalence of SLE compared with BMI as the dominant factor that regulates gastrointestinal microbial metabolism and provide plausible explanatory causes. Our results uncover novel perspectives with clinical relevance for human biology. In particular, we rank the importance of various pathophysiologies for gut homeostasis. 2015-04-24T10:52:28Z 2015-04-24T10:52:28Z 2015 journal article Rojo, D.; et al. Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases. Scientific Reports, 5: 8310 (2015). [doi: 10.1038/srep08310] 2045-2322 http://hdl.handle.net/10481/35792 10.1038/srep08310 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ open access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Nature Publishing Group