<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
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      <dc:title>Different presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii in schizophrenia: meta-analysis and analytical study</dc:title>
      <dc:creator>Gutiérrez-Fernández, José</dc:creator>
      <dc:creator>Luna Del Castillo, Juan De Dios</dc:creator>
      <dc:creator>Mañanes-González, Sara</dc:creator>
      <dc:creator>Carrillo-Ávila, José Antonio</dc:creator>
      <dc:creator>Gutiérrez, Blanca</dc:creator>
      <dc:creator>Cervilla, Jorge A.</dc:creator>
      <dc:creator>Sorlozano Puerto, Antonio</dc:creator>
      <dc:subject>Meta-analysis</dc:subject>
      <dc:subject>Analytical study</dc:subject>
      <dc:subject>Chlamydia pneumoniae</dc:subject>
      <dc:subject>Herpes simplex virus type 1</dc:subject>
      <dc:subject>Human herpes virus 6</dc:subject>
      <dc:subject>Toxoplasma gondii</dc:subject>
      <dc:subject>Schizophrenia</dc:subject>
      <dc:description>In the present study we have performed both a meta-analysis and an analytical study exploring the presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii antibodies in a sample of 143 schizophrenic patients and 143 control subjects. The meta-analysis was performed on papers published up to April 2014. The presence of serum immunoglobulin G and immunoglobulin A was performed by enzyme-linked immunosorbent assay test. The detection of microbial DNA in total peripheral blood was performed by nested polymerase chain reaction. The meta-analysis showed that: 1) C. pneumoniae DNA in blood and brain are more common in schizophrenic patients; 2) there is association with parasitism by T. gondii, despite the existence of publication bias; and 3) herpes viruses were not more common in schizophrenic patients. In our sample only anti-Toxoplasma immunoglobulin G was more prevalent and may be a risk factor related to schizophrenia, with potential value for prevention.</dc:description>
      <dc:date>2015-04-17T10:56:23Z</dc:date>
      <dc:date>2015-04-17T10:56:23Z</dc:date>
      <dc:date>2015</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Gutiérrez-Fernández, J.; et al. Different presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii in schizophrenia: meta-analysis and analytical study. Neuropsychiatric Disease and Treatment, 11: 843-852 (2015). [http://hdl.handle.net/10481/35709]</dc:identifier>
      <dc:identifier>1178-2021</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/35709</dc:identifier>
      <dc:identifier>10.2147/NDT.S79285</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/3.0/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License</dc:rights>
      <dc:publisher>Dove Press</dc:publisher>
   </ow:Publication>
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