An Ex Vivo Model in Human Femoral Heads for Histopathological Study and Resonance Frequency Analysis of Dental Implant Primary Stability Hernández-Cortés, Pedro Monje, Alberto Galindo Moreno, Pablo Antonio Catena Martínez, Andrés Ortega-Oller, Inmaculada Salas-Pérez, José Mesa Aguado, Francisco Luis Gómez Sánchez, Rafael Aguilar Peña, Mariano Aguilar Peña, David O'Valle Ravassa, Francisco Javier Resonance frequency analysis (RFA) Dental implants Human femoral heads Objective. This study was designed to explore relationships of resonance frequency analysis (RFA)—assessed implant stability (ISQ values) with bone morphometric parameters and bone quality in an ex vivo model of dental implants placed in human femoral heads and to evaluate the usefulness of this model for dental implant studies. Material and Methods. This ex vivo study included femoral heads from 17 patients undergoing surgery for femoral neck fracture due to osteoporosis (OP) ( ) or for total prosthesis joint replacement due to severe hip osteoarthrosis (OA) ( ). Sixty  mm Dentsply Astra implants were placed, followed by RFA. CD44 immunohistochemical analysis for osteocytes was also carried out. Results. As expected, the analysis yielded significant effects of femoral head type (OA versus OA) ( ), but not of the implants ( ) or of the interaction of the two factors ( ). Bonferroni post hoc comparisons showed a lower mean ISQ for implants in decalcified ( ) heads than in fresh ( ) or fixated ( ) heads (both ). The ISQ score (fresh) was significantly higher for those in OA ( ) versus OP ( ) heads. However, mixed linear analysis showed no significant association between ISQ scores and morphologic or histomorphometric results ( in all cases), and no significant differences in ISQ values were found as a function of the length or area of the cortical layer (both ). Conclusion. Although RFA-determined ISQ values are not correlated with morphometric parameters, they can discriminate bone quality (OP versus OA). This ex vivo model is useful for dental implant studies. 2015-04-09T11:03:39Z 2015-04-09T11:03:39Z 2014 journal article Hernández-Cortés, P.; et al. An Ex Vivo Model in Human Femoral Heads for Histopathological Study and Resonance Frequency Analysis of Dental Implant Primary Stability. BioMed Research International, 2014: 535929 (2014). [http://hdl.handle.net/10481/35486] 2314-6133 2314-6141 http://hdl.handle.net/10481/35486 10.1155/2014/535929 eng open access Hindawi Publishing Corporation