Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up Arrebola Moreno, Juan Pedro Fernández, Mariana F. Martín-Olmedo, Piedad Molina-Molina, José-Manuel Sánchez Pérez, María José Sánchez-Cantalejo Ramírez, Emilio Molina Portillo, Elena Expósito Hernández, José Bonde, Jens Peter Olea Serrano, Nicolás Persistent organic pollutants Adipose tissue Cancer Prospective study Hazard ratio Follow-up There is an increasing trend in the incidence of cancer worldwide, and it has been accepted that environmental factors account for an important proportion of the global burden. The present paper reports preliminary findings on the influence of the historical exposure to a group of persistent organic pollutants on total cancer risk, at year 9 in the follow-up of a cohort from Southern Spain. A cohort of 368 participants (median age 51 years) was recruited in 2003. Their historical exposure was estimated by analyzing residues of persistent organic pollutants in adipose tissue. Estimation of cancer incidence was based on data from a population-based cancer registry. Statistical analyses were performed using multivariable Cox-regression models. In males, PCB 153 concentrations were positively associated with total cancer risk, with an adjusted hazard ratio (95% confidence interval) of 1.20 (1.01–1.41) for an increment of 100 ng/g lipid. Our preliminary findings suggest a potential relationship between the historical exposure to persistent organic pollutants and the risk of cancer in men. However, these results should be interpreted with caution and require verification during the future follow-up of this cohort. 2015-02-02T13:50:15Z 2015-02-02T13:50:15Z 2014 preprint Arrebola, J.P.; et al. Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up [pre-print]. Science of the Total Environment, 500-501: 243-249 (2014). [http://hdl.handle.net/10481/34557] 0048-9697 http://hdl.handle.net/10481/34557 10.1016/j.scitotenv.2014.08.043 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ open access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Elsevier