Association of 25-hydroxyvitamin D with Metabolic Syndrome in Patients with Psoriasis: A Case-control Study Orgaz Molina, Jacinto Magro-Checa, César Arrabal Polo, Miguel Ángel Raya Álvarez, Enrique Germán Naranjo Sintes, Ramón José Buendía Eisman, Agustín Arias Santiago, Salvador Antonio Psoriasis Vitamin D Metabolic syndrome Cardiovascular risk Vitamin D deficiency is associated with higher cardiovascular risk and metabolic syndrome (MeS) criteria. The main objective of this study was to analyse the association of 25-hydroxyvitamin D (25-OHD) serum levels with MeS (National Cholesterol Education Program Adult Treatment Panel-III criteria) in 46 Spanish patients with psoriasis, but without arthritis and systemic treatment, and 46 control subjects, matched by sex and age. The patients with psoriasis showed significantly lower level of 25-OHD than controls (30.5 vs. 38.3 ng/ml; p =0.0001). Patients with MeS had significantly lower serum levels of 25-OHD than those without MeS (24.1 +/- 7.5 vs. 32.8 +/- 8.9,p =0.007), and a negative correlation was found between 25-OHD and waist circumference, diastolic blood pressure, fasting glucose, and triglyceridaemia. In the control group no significant correlation between 25-OHD and MeS was found. Although the sample was small, our results suggest a potential protective role for 25-OHD in the metabolic profile of patients with psoriasis without arthritis. 2014-04-23T09:13:07Z 2014-04-23T09:13:07Z 2014 journal article Orgaz-Molina, J.; et al. Association of 25-hydroxyvitamin D with Metabolic Syndrome in Patients with Psoriasis: A Case-control Study. Acta Demato-Venereologica, 94: 142-145 (2014). [http://hdl.handle.net/10481/31356] 0001-5555 1651-2057 http://hdl.handle.net/10481/31356 10.2340/00015555-1642 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ open access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Society for the Publication of Acta Dermato - Venereologica