Worldwide topology of the scientific subject profile: a macro approach in the country level Moya Anegón, Félix de Herrero Solana, Víctor Science Indicators Collaboration [Background] Models for the production of knowledge and systems of innovation and science are key elements for characterizing a country in view of its scientific thematic profile. With regard to scientific output and publication in journals of international visibility, the countries of the world may be classified into three main groups according to their thematic bias. [Methodology/Principal Findings] This paper aims to classify the countries of the world in several broad groups, described in terms of behavioural models that attempt to sum up the characteristics of their systems of knowledge and innovation. We perceive three clusters in our analysis: 1) the biomedical cluster, 2) the basic science & engineering cluster, and 3) the agricultural cluster. The countries are conceptually associated with the clusters via Principal Component Analysis (PCA), and a Multidimensional Scaling (MDS) map with all the countries is presented. [Conclusions/Significance] As we have seen, insofar as scientific output and publication in journals of international visibility is concerned, the countries of the world may be classified into three main groups according to their thematic profile. These groups can be described in terms of behavioral models that attempt to sum up the characteristics of their systems of knowledge and innovation. 2014-01-31T08:05:30Z 2014-01-31T08:05:30Z 2013 info:eu-repo/semantics/article Moya-Anegón, F.; Herrero-Solana, V. Worldwide topology of the scientific subject profile: a macro approach in the country level. Plos One, 8(12): e83222 (2013). [http://hdl.handle.net/10481/30084] 1932-6203 doi: 10.1371/journal.pone.0083222 http://hdl.handle.net/10481/30084 eng info:eu-repo/semantics/openAccess Public Library of Science (PLOS)