<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/111261">
      <dc:title>Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli</dc:title>
      <dc:creator>Rodríguez Pérez, Celia</dc:creator>
      <dc:creator>Quirantes-Piné, Rosa</dc:creator>
      <dc:creator>Uberos Fernández, José</dc:creator>
      <dc:creator>Jiménez-Sánchez, Cecilia</dc:creator>
      <dc:creator>Peña, Alejandro</dc:creator>
      <dc:creator>Segura Carretero, Antonio</dc:creator>
      <dc:subject>Cranberry</dc:subject>
      <dc:subject>Semipreparative-HPLC</dc:subject>
      <dc:subject>Phenolic compounds</dc:subject>
      <dc:subject>Adherence</dc:subject>
      <dc:subject>Biofilm</dc:subject>
      <dc:subject>Surface hydrophobicity</dc:subject>
      <dc:subject>Escherichia coli</dc:subject>
      <dc:description>This work was supported by the projects AGL2011-29857-C03-02, P09-CTS-4564, P10-FQM-6563, and P11-CTS-7625 (Andalusian Regional Government Council of Innovation and Science) and PI070274 (Carlos III Institute of Health for Clinical Research, Madrid, Spain). The authors are grateful to the Spanish Ministry of Economy and Competitiveness (MINECO) for a FPU fellowship AP2010-1551 (Spanish Ministry of Science and Innovation) (C. Rodríguez-Pérez), and a grant “Personal técnico de apoyo” PTA2012-6956-E (R. Quirantes-Piné).</dc:description>
      <dc:description>Phenolic compounds from a cranberry extract were isolated in order to assess their contribution to the antibacterial activity against urophatogenic strains of Escherichia coli (UPEC). With this purpose, a total of 25 fractions from a cranberry extract were isolated using semipreparative high performance liquid chromatography (HPLC) and characterized based on the results obtained by reversed-phase HPLC coupled to mass spectrometry detection. Then, the effect on UPEC surface hydrophobicity and biofilm formation of the cranberry extract as well as the purest fractions (a total of 13) was tested. As expected, the whole extract presented a powerful antibacterial activity against UPEC while the selected fractions presented different behavior. Myricetin and quercitrin significantly decreased (p &lt; 0.05) E. coli biofilm formation compared with the control, while dihydroferulic acid glucuronide, procyanidin A dimer, quercetin glucoside, myricetin and prodelphinidin B led to a significant decrease on the surface hydrophobicity compared with the control. The results suggest that apart from procyanidins, other compounds, mainly flavonoids, can act against E. coli biofilm formation and also modify UPEC surface hydrophobicity in vitro, one of the first steps of adhesion.</dc:description>
      <dc:date>2026-02-19T11:57:39Z</dc:date>
      <dc:date>2026-02-19T11:57:39Z</dc:date>
      <dc:date>2016</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Published version: Rodríguez-Pérez, Celia. Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli. Food Funct. 2016; 7(3): 1564-73. https://doi.org/10.1039/C5FO01441G</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/111261</dc:identifier>
      <dc:identifier>10.1039/C5FO01441G</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 Internacional</dc:rights>
      <dc:publisher>Royal Society of Chemistry</dc:publisher>
   </ow:Publication>
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