Emerging Therapeutics Target in Regenerative Medicine fot the Treatment of Diabetes Mellitus: A Patent Literature Review Álvarez-Mercado, Anabel Cobo-Vuilleumier, Nadia Suárez Martín, Eduardo Benoit, Gauthier Apoptosis Diabetes mellitus Regenerative Medicine El texto completo no está disponible en acceso abierto por restricciones de copyright We would like to acknowledge Dr. L. St-Onge for his fruitful discussions. Part of the work described herein was funded by the Consejeria de Salud, Junta de Andalucia (PI0727/ 2010 to B.R.G) and from the Fundacion Publica Andaluza Progreso y Salud. The corresponding author would like to dedicate this article in memory of Dr Ulrich Vischer, a colleague and friend, who was tragically killed in an snow avalanche in Norway in March 2012. In recent years, the concept of preserving and/or replenishing the functional B-cell mass vital to sustain insulin output and normalized blood glucose levels has gained much interest as a therapeutic approach in regenerative medicine for the treatment of Diabetes Mellitus. Herein we surveyed the diabetes area patent literature published in recent years to identify novel uprising therapeutic targets specifically implicated in regeneration and survival. One hundred and sixty nine International Patent Applications filed under the Patent Cooperation Treaty (PCT) (hereinafter, patents or applications) were highlighted from which 8 particular targets stood out with more than 4 patents published within the last few years. Not surprisingly, GLP-1 analogues and DPP-4 inhibitors along with GPR119 agonists and SGLT2 inhibitors were among the top ranked candidates. However, new emerging targets into the field of regenerative medicine for the treatment of diabetes include: 1) BACE-2; a protease that was recently shown to cleave the plasma membrane glycoprotein TMEM27 (also called collectrin) resulting in the inhibition of pancreatic cell proliferation and insulin secretion, 2) GIP; a 42 amino acid incretin hormone that potentiates glucose induce insulin secretion and protect b-cells against cytokinemediated apoptosis, 3) neurturin; a neurotrophic factor capable of improving blood glucose levels in high fat diet treated animals, and 4) LRH-1, an orphan nuclear receptor that improves islet viability. These novel targets along with GPR119 are further discussed in this review. 2026-02-02T13:49:14Z 2026-02-02T13:49:14Z 2013 journal article Álvarez-Mercado, A.; Cobo-Vuilleumier, N.; Suárez Martín, E. y Benoit, G. (2013). Emerging Therapeutics Target in Regenerative Medicine fot the Treatment of Diabetes Mellitus: A Patent Literature Review. Recent Patents on Regenerative Medicine. 3(1): 56- 62. http://doi.org/10.2174/2210296511303010056 https://hdl.handle.net/10481/110596 10.2174/2210296511303010056 eng embargoed access Bentham Science Publishers