Anti-diabetic and anti-parasitic properties of a family of luminescent zinc coordination compounds based on the 7-amino-5-methyl-1,2,4-triazolo[1,5- a]pyrimidine ligand Esteban Parra, Ginés Miguel San Sebastián, Eider Cepeda, Javier Sánchez González, Cristina Rivas García, Lorenzo Llopis González, Juan Aranda Ramírez, Pilar Sánchez Moreno, Manuel Quirós Olozábal, Miguel Rodríguez Diéguez, Antonio We report on the formation of a triazolopyrimidine derivative ligand, 7-amino-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine (7-amtp), and a new family of coordination compounds based on this ligand and zinc as metal ion, synthesized by conventional routes. These materials possess different mononuclear structures, namely [ZnCl2(7-amtp)2] (1), [Zn(7-amtp)2(H2O)4](NO3)2·2(7-amtp)·6H2O (2) and [Zn(7-amtp)2(H2O)4](SO4)·1.5H2O (3) derived from the use of different zinc (II) salts, in such a way that the counterions govern the crystallization to a large extent. These compounds present and show variable luminescent properties based on ligand-centred charge transfers which have been deeply studied by Time Dependent Density Functional Theory (TD-DFT) calculations. When these compounds are transferred to solution, preserving complex entities as corroborated by NMR studies, they present interesting anti-diabetic and anti-parasitic capabilities, with a comparatively higher selectivity index than other previously reported triazolopyrimidine-based materials. The results derived from in vivo experiments conducted in mice also confirm their promising activity as anti-diabetic drug being capable of dropping glucose levels after oral administration. Therefore, these new materials may be considered as excellent candidates to be further investigated in the field of luminescent coordination compounds with biomedical applications. 2026-01-27T10:36:50Z 2026-01-27T10:36:50Z 2020 journal article Esteban-Parra GM, Sebastián ES, Cepeda J, Sánchez-González C, Rivas-García L, Llopis J, Aranda P, Sánchez-Moreno M, Quirós M, Rodríguez-Diéguez A. Anti-diabetic and anti-parasitic properties of a family of luminescent zinc coordination compounds based on the 7-amino-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine ligand. J Inorg Biochem. 2020 Nov;212:111235. doi: 10.1016/j.jinorgbio.2020.111235. https://hdl.handle.net/10481/110319 https://doi.org/10.1016/j.jinorgbio.2020.111235 eng open access