Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease Rivas García, Lorenzo Quiles Morales, José Luis Roma-Rodrigues, Catarina Raposo, Luis Navarro Hortal, María Dolores Romero Márquez, José Manuel Esteban-Muñoz, Adelaida Varela López, Alfonso Carrera García, Laura Cianciosi, Danila Forbes Hernández, Tamara Yuliett Battino, Maurizio Llopis González, Juan Fernandes, Alexandra Baptista, Pedro Sánchez González, Cristina Edible flowers are being used as a new ingredient in modern gastronomy. Recently, these products have also gained interest as an important source of phenolic compounds with potential for biomedical applications. The present work studied a methanolic extract of Rosa x hybrida in which 35 individual phenolic compounds were identified. The extract has been evaluated for its antiproliferative properties in ovarian carcinoma cells. Results showed that the antiproliferative effect was associated with the induction of autophagy and apoptosis with the concomitant ROS increase probably related to mitochondria dysfunction. These antiproliferative effects might be associated with some components of the extract such as quercetin. The extract did not induce damage in healthy cells and that it was able to improve the wound healing activity. The present study also evaluated the properties of the mentioned extract in vivo in C. elegans. Tests demonstrated a lack of toxicity in the worm model. Promising results have been obtained in transgenic strains of C. elegans that produce human beta amyloid peptide, suggesting the possible utility of the extract from the point of view of Alzheimer disease. Altogether, results suggest that Rosa x hybrida extracts could be a new tool for the development of functional foods. 2026-01-26T08:22:08Z 2026-01-26T08:22:08Z 2021 journal article Rivas-García L, Quiles JL, Roma-Rodrigues C, Raposo LR, Navarro-Hortal MD, Romero-Márquez JM, Esteban-Muñoz A, Varela-López A, García LC, Cianciosi D, Forbes Hernández TY, Battino M, Llopis J, Fernandes AR, Baptista PV, Sánchez-González C. Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease. Food Chem Toxicol. 2021 Mar;149:112018. doi: 10.1016/j.fct.2021.112018. https://hdl.handle.net/10481/110211 https://doi.org/10.1016/j.fct.2021.112018 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ open access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Elsevier