Intraoral exophytic lesion in an adolescent: a case report of myoepithelioma with unique clinical presentation Urias-Barreras, Cynthia M. Soto Sañudo, Ana Karen Vega Imperial, Jorge Rodríguez Archilla, Alberto Adolescent Buccal mucosa Myoepithelioma This work was supported by the Autonomous University of Sinaloa [PROFAPI PRO_A3_027]. Myoepithelioma is an infrequent benign tumor of the salivary glands, characterized by its composition of myoepithelial cells which can show different shapes and be arranged in various patterns with a well-circumscribed or encapsulated growth. This tumor commonly presents in adults as an asymptomatic swelling of the parotid gland, very rarely in minor salivary glands of children or adolescents, and even rarer in the buccal mucosa, with only six cases reported to date and only one of them presented in an adolescent. We present an additional case of myoepithelioma in the buccal mucosa of a 16-year-old male, with a novel clinical presentation as a non-submucosal exophytic mass. Immunohistochemically, neoplastic cells were positive for CK, S100, p63, and GFAP. The tumour was treated surgically, and the patient showed satisfactory evolution at 1 year of follow-up. The clinical and histopathological characteristics of the reported cases are discussed. 2026-01-16T09:13:53Z 2026-01-16T09:13:53Z 2023-09 journal article Publisher version: Urias Barreras CM, Soto Sañudo AK, Vega Imperial J, Rodríguez Archilla A. Intraoral exophytic lesion in an adolescent: a case report of myoepithelioma with unique clinical presentation. J Stomatol Oral Maxillofac Surg. Volume 124, Issue 4, September 2023, 101419. https://doi.org/10.1016/j.jormas.2023.101419 2468-7855 https://hdl.handle.net/10481/109783 10.1016/j.jormas.2023.101419. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier