Prevalence of the endolymphatic sac hypoplasia in a cohort of individuals without Meniere disease Robles Bolívar, Paula Martínez Martínez, Marta Martín-Márquez, Rocío Berrio-Domínguez, Inés Martín Rodríguez, José Luis Lopez-Escamez, Jose Antonio Diseases Meniere Endolymphatic sac Purpose: To estimate the prevalence of endolymphatic sac hypoplasia (EShp)—a proposed specific finding in Menière ´ ’s disease (MD) that defines an endophenotype characterized by bilateral involvement, male predominance, temporal bone abnormalities, and familial clustering—in individuals without MD, to assess its specificity for the condition. Methods: We analyzed 956 temporal bone CT scans from individuals without MD to assess the prevalence of EShp using the Angular Trajectory of the Vestibular Aqueduct (ATVA) marker. ATVA distribution, reproducibility, and associations with clinical variables were also evaluated. Results: EShp was identified in 6 ears from 4 individuals, yielding a prevalence of 0.6% per patient and 0.8% per ear. ATVA values had a median of 95.0° (IQR = 12.5°, range 65.9°–159.4°). Interobserver agreement was good (ICC = 0.75), with a mean bias of 6.2° ± 5.4° and 5.5% of ears outside the 95% limits of agreement. No significant associations were found between ATVA and sex, age, or clinical diagnosis. Conclusions: EShp is rare in individuals without MD, supporting its specificity and potential role in MD pathophysiology. The ATVA marker is reliable and reproducible and may serve as a CT biomarker for the hypoplastic MD endophenotype. 2025-12-16T11:06:33Z 2025-12-16T11:06:33Z 2025-08-25 journal article Robles-Bolivar P, Martínez-Martínez M, Martín-Márquez R, Berrio-Domínguez I, Martin-Rodríguez JL, Lopez-Escamez JA. Prevalence of the endolymphatic sac hypoplasia in a cohort of individuals without Meniere disease. Journal of Vestibular Research. 2025;0(0). doi: 10.1177/09574271251371541 https://hdl.handle.net/10481/108853 10.1177/09574271251371541 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Sage