Systemic inflammatory impact of periodontitis on cognitive impairment Gil Montoya, José Antonio Barrios Rodríguez, Rocío Sanchez‐Lara, Inés Ramos García, Pablo Carnero, Cristobal Fornieles Rubio, Francisco Montes, Juan Santana, Soraya Luna Del Castillo, Juan De Dios González Moles, Miguel Ángel Alzheimer’s disease biomarkers; cytokines cytokines inflammation periodontal disease Objectives: The role in dementia of systemic inflammation derived from periodontal disease is not fully elucidated. The objective of our study was to examine the impact of inflammation on the relationship between periodontitis and cognitive impairment. Methods: We have designed a case (n = 171) and control (n = 131) study to determine the periodontal health status, grade of cognitive impairment/dementia and systemic inflammation level, the last being measured by analysis of 29 inflammatory biomarkers using multiplex techniques. Results: At the time of sampling, 11 of the 29 inflammatory biomarkers were associated with cognitive impairment in patients with more severe periodontitis. However, the inflammatory response to severe periodontitis was more reduced (lower biomarker concentrations) in cases (with cognitive impairment or dementia) than in (cognitively healthy) controls, an unexpected finding. Conclusions: Based on these results, we cannot confirm that systemic inflammation derived from periodontal disease plays a relevant role in the aetiology of cognitive impairment 2025-12-05T12:25:00Z 2025-12-05T12:25:00Z 2020 journal article Gil Montoya JA, Barrios R, Sanchez-Lara I, Ramos P, Carnero C, Fornieles F, Montes J, Santana S, Luna JD, Gonzalez-Moles MA. Systemic inflammatory impact of periodontitis on cognitive impairment. Gerodontology. 2020 Mar;37(1):11-18. doi: 10.1111/ger.12431. https://hdl.handle.net/10481/108628 10.1111/ger.12431 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ embargoed access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Wiley