Relationship between salivary lactoferrin level and brain amyloid load in periodontal and non-periodontal subjects. Gil Montoya, José Antonio Gerez-Muñoz, María José Triviño-Ibañez, Eva María Rosel Gallardo, Eva María Bravo Pérez, Manuel Romero Fábrega, Juan Carlos Morales Santana, Sonia Gómez Río, Manuel Alzheimer’s disease periodontal disease saliva lactoferrin amyloid load. This research has been co-financed by the FEDER Operational Program 2014-2020 and by the Regional Ministry of Economy, Knowledge, Business, and University of the Regional Government of Andalusia. Background: Lactoferrin in saliva has been proposed as a possible diagnostic biomarker for Alzheimer's disease, as it is associated with ß-amyloid load in the brain. The aim of this study was to find out whether there is an association between salivary lactoferrin and cerebral ß-amyloid load and the involvement of periodontal disease in this possible connection. Material and methods: Six exploratory comparison groups were designed: participants with mild cognitive impairment (n=50) (positive PET-amyloid with and without periodontal disease and negative PET-amyloid with and without periodontal disease) and cognitively normal older individuals with and without periodontal disease (n=19). All participants were recruited from referral hospitals in Granada, Spain, and from a nursing home in the same socio-economic area as the hospital participants. A salivary lactoferrin determination and a periodontal assessment has been performed in each of the participants. Results: The results show that both having an atypical ß-amyloid load in the brain (PET+) and having periodontal disease are clearly associated with a lower concentration of salivary lactoferrin (p=0.011 and p=0.032), but not with age or gender. Conclusions: In this studio, the positive PET-amyloid and periodontal disease are related independently with lower lactoferrin levels. 2025-12-05T08:44:26Z 2025-12-05T08:44:26Z 2025-10-18 journal article Gil-Montoya JA, Gerez-Muñoz MJ, Triviño-Ibáñez EM, Rosel E, Bravo M, Rómero- Fábrega JC, Morales-Santana S, Gómez-Río M. Relationship between salivary lactoferrin level and brain amyloid load in periodontal and non-periodontal subjects. Med Oral Patol Oral Cir Bucal. 2025 Oct 18:27612. doi: 10.4317/medoral.27612 https://hdl.handle.net/10481/108607 10.4317/medoral.27612 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Medicina Oral S.L.