Periodontal disease and brain amyloid pathology in mild cognitive impairment Gil Montoya, José Antonio Gerez-Muñoz, M.J. Triviño-Ibañez, Eva María Carrera Muñoz, Ismael Bravo Pérez, Manuel Rashki, Mahsa Solís Urra, Patricio Esteban Cornejo, Irene Gómez Río, Manuel Periodontal disease Alzheimer disease Beta-amyloid Mild cognitive impairment Amyloid-PET scan The assessment of the cognitively healthy group was partially supported by the AGUEDA study (Ref: I+ D+ iRTI2018-095284-J-I00; 2018). For the remaining comparison groups, no specific grant was received from funding agencies in the public, commercial, or non-profit sectors. Introduction: Increases in brain -amyloid protein (A) levels have been demonstrated in animal models following oral inoculation of periodontopathogens or their enzyme gingipain. We investigated the association between periodontitis and brain A protein levels in mild cognitive impairment (MCI). Methods: An observational study was designed. All participants underwent a periodontal examination and an amyloid-PET scan. Subsequently, the following groups were established: MCI and suspected Alzheimer disease (AD) (MCI/A+ group) (n = 45); MCI and suspected non-AD pathology (MCI/A— group) (n = 59); cognitively healthy elderly individuals Results: Patients with moderate-severe periodontitis had a higher risk of abnormal accumulation of A in the brain, with an odds ratio (OR) of 3.30 (95% confidence interval [CI], 1.30—8.26) when comparing patients from the MCI/A+ and MCI/A— groups, and an OR of 4.94 (95% CI, 1.65—14.84) when comparing the MCI/A+ group against the non-MCI/A— group. Conclusions: Our findings suggest that periodontal disease may be associated with anomalous accumulation of cerebral A protein in older people, independently of cognitive impairment. 2025-12-05T07:43:28Z 2025-12-05T07:43:28Z 2025-09 journal article Gil-Montoya JA, Gerez-Muñoz MJ, Triviño-Ibáñez E, Carrera-Muñoz I, Bravo M, Rashki M, Solis-Urra P, Esteban-Cornejo I, Gómez-Río M. Periodontal disease and brain amyloid pathology in mild cognitive impairment. Neurologia (Engl Ed). 2025 Sep;40(7):641-650. doi: 10.1016/j.nrleng.2025.07.008 https://hdl.handle.net/10481/108602 10.1016/j.nrleng.2025.07.008 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier