<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/108536">
      <dc:title>Psychological intervention in patients with central sensitization syndromes and comorbid psychosocial trauma: a systematic review and meta-analysis</dc:title>
      <dc:creator>Maire, Coralie</dc:creator>
      <dc:creator>Sánchez, Ana. I.</dc:creator>
      <dc:creator>Ventura-Lucena, José María</dc:creator>
      <dc:creator>Miró Morales, María Elena</dc:creator>
      <dc:creator>Martínez, M. Pilar</dc:creator>
      <dc:subject>Psychological intervention</dc:subject>
      <dc:subject>Central sensitization syndromes</dc:subject>
      <dc:subject>Post-traumatic stress disorder</dc:subject>
      <dc:description>This study is part of a broader research project supported by the Spanish Ministry of Science and Innovation&#xd;
and Spanish State Research Agency (project PID2019-109612GB-I00, funded by MCIN/AEI/https://doi.org/10&#xd;
.13039/501100011033).</dc:description>
      <dc:description>The co-occurrence of central sensitization syndromes (CSS) and post-traumatic symptoms (PTSS) or&#xd;
post-traumatic stress disorder (PTSD) exacerbates impairment, and treatment is unsatisfactory in&#xd;
many cases. This systematic review and meta-analysis examined the effectiveness of psychological&#xd;
therapy in individuals with CSS and comorbid PTSS/PTSD. A search of Medline, PsycInfo, Web of&#xd;
Science, Pubmed, and Scopus databases (2000 to 2023) was conducted following PRISMA guidelines.&#xd;
Nineteen articles were selected, including nine for meta-analysis. The main psychological therapies&#xd;
were pain-focused cognitive-behavioral therapy (P-CBT), and trauma-focused interventions, mainly&#xd;
written emotional disclosure (WED) and emotional awareness and expression therapy (EAET). Both&#xd;
EAET and P-CBT showed potential benefits in improving pain severity (specially EAET), PTSS/PTSD,&#xd;
emotional distress, fatigue, sleep disturbances, CSS-related symptoms, and quality of life. Overall, no&#xd;
significant differences were found between the two interventions. The meta-analysis revealed a large&#xd;
effect size for EAET in reducing pain and emotional distress; however, most comparison were against&#xd;
inactive controls, so results should be interpreted cautiously. These findings underscore the importance&#xd;
of distinguishing CSS patients with PTSS/PTSD. Tailored treatments such as EAET can address the&#xd;
additive impact of these conditions and contribute to improving patients’ quality of life.</dc:description>
      <dc:date>2025-12-03T07:59:18Z</dc:date>
      <dc:date>2025-12-03T07:59:18Z</dc:date>
      <dc:date>2025-08-22</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Maire C, Sánchez AI, Ventura-Lucena JM, Miró E, Martínez MP. Psychological intervention in patients with central sensitization syndromes and comorbid psychosocial trauma: a systematic review and meta-analysis. Sci Rep. 2025 Aug 22;15(1):30896. doi: 10.1038/s41598-025-16074-6. PMID: 40847104; PMCID: PMC12373779.</dc:identifier>
      <dc:identifier>2045-2322</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/108536</dc:identifier>
      <dc:identifier>10.1038/s41598-025-16074-6</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 Internacional</dc:rights>
      <dc:publisher>Nature portfolio</dc:publisher>
   </ow:Publication>
</rdf:RDF>